One of our most famous examples in chemistry and possibly our most memorable from Strem Chemicals is the prototype of palladium cross-coupling catalysts, always in stock in the UK. A vivid yellow!

Tetrakis (triphenylphosphine)palladium(0), or Pd(PPh3)4, is perhaps the best-known catalyst for classical cross-coupling reactions. As evidenced by greater than 12,000 references in SciFinder, Pd(PPh3)4 is a workhorse of Pd(0)-catalyzed transformations and stands as the prototype upon which a diverse collection of palladium catalysts have been built.

In the solid state, Pd(PPh3)4 adopts a tetrahedral geometry1,, consistent with its 18-electron configuration (Figure 1). Though its homoleptic structure is relatively simple, the complex has been applied to an impressive variety of reactions. The most notable of these are cross-coupling reactions between aryl halides and transmetalating reagents, which were the subject of the 2010 Nobel Prize in Chemistry jointly awarded to Professors. Negishi2, Suzuki3, and Heck4  In addition, the Sonogashira5 and Stille6 coupling reactions utilize Pd(PPh3)4 to facilitate transmetalation reactions between alkynes and tin reagents. see our website for more graphics

High quality pure Pd(PPh3)4 exhibits a beautiful golden-yellow color (Figure 3). Low quality or decomposed material however, often shows a dark orange-brown color or, in extreme cases of decay, a dark greenish color. This allows one to perform their own quality control: if it looks good, it is good! From milligrams to kilograms, Strem offers tetrakis-triphenylphosphine palladium(0) with consistently high quality, and the complex continues to be an invaluable part of any synthetic organic chemist’s toolbox.

Featured Product:
46-2150: Tetrakis(triphenylphosphine)palladium(0), 99% (99.9+%-Pd) (14221-01-3)



  1. Zh. Strukt. Khim 1976, 17, 135.  CCDC deposition number 1275987
  2. J. Org. Chem. 2007, 72, 4246.
  3. J. Am. Chem. Soc., 2009, 131, 5024.
  4. J. Am. Chem. Soc. 1974, 96, 1133.
  5. Tetrahedron Lett. 1965, 16: 4467–4470.
  6. Chem. Lett., 1977, 6, 301-302.


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